Dr Ruth Pepper

BSC, MBBS, MRCP, PHD

Consultant Nephrologist

Dr Ruth Pepper is a consultant Nephrologist at the Royal Free Hospital. She qualified from UCL medical school in 2003 having trained in Nephrology at the Hammersmith Hospital, Royal London Hospital and the Royal Free Hospital.

Dr Pepper completed her PhD at UCL Centre for Nephrology in Glomerulonephritis in 2013 and competed training as an Academic Clinical Lecturer at the Royal Free Hospital. She was appointed as a Consultant in 2015.

Her subspecialty interest is in renal autoimmune disease. This includes lupus, vasculitis and nephrotic syndrome.

Dr Pepper is also involved in some clinical studies at the Royal Free Hospital. She is a member of the Renal Association and is involved in clinical research at the Royal Free.

Hospital Locations

Royal Free Hospital

Year qualified

2003

Country of qualification

Languages spoken

English

Specialities

Nephrology

Memberships

Renal Association
Royal College of Physicians

Procedures offered

Haemodialysis
Peritoneal dialysis

Clinical interests

General Nephrology
Lupus
Vasculitis
Nephrotic syndrome

Research interests

Glomerulonephrits
Vasculitis
Lupus nephrits

Published papers

Gupta S, Connolly J, Pepper RJ, Walsh SB, Yaqoob MM, Kleta R, Ashman N.
Membranous nephropathy: a retrospective observational study of membranous nephropathy in north east and central London. BMC Nephrol 2017;18(1):201.
RJ Pepper, JB Draibe, B Caplin,FC Fervenza, GS Hoffman, CGM Kallenberg, CA Langford, PA Monach, P Seo, R Spiera, EW St Clair, NK Tchao, J Stone, U Specks, PA Merkel, AD Salama; for RAVE-ITN Research Group. The association of serum calprotectin (S100A8/S100A9) levels with disease relapses in PR3-ANCA-associated vasculitis. Arthritis and Rheumatology 2017; 69(1):185-193
Pepper RJ, Lachmann HJ. Autoinflammatory syndromes in children. Indian Journal of Paediatrics. 2016 Mar;83(3):242-7
Hamour S, Gan PY, Pepper R, Florez Barros F, Wang HH, O’Sullivan K, Iwakura Y, Cook T, Pusey C, Holdsworth S, Salama A. Local IL-17 Production Exerts a Protective Role in Murine Experimental Glomerulonephritis. PLoS One. 2015 Aug 28;10(8
Pepper RJ, Wang HH, Rajakaruna GK, Papakrivopoulou E, Vogl T, Pusey CD, Cook
HT, Salama AD. S100A8/A9 (Calprotectin) Is Critical for Development of Glomerulonephritis and Promotes Inflammatory Leukocyte-Renal Cell Interactions
Am J Pathol. 2015 May;185(5):1264-74
Todd SK, Pepper RJ, Draibe J, Tanna A, Pusey CD, Mauri C, Salama AD. Regulatory B cells are numerically but not functionally deficient in anti-neutrophil cytoplasm antibody (ANCA) associated vasculitis. Rheumatology 2014 Sep; 53(9):1693-703.
Turner-Stokes T*, Sandhu E*, Pepper RJ*, Stolagiewicz NE, Ashley C, Dinneen D, Howie AJ, Salama AD, Burns A, Little MA. Induction treatment of ANCA Associated Vasculitis with a single dose of rituximab. Rheumatology. 2014 Aug;53(8):1395-403
Lavainne F, Meffray E, Pepper RJ, Néel M, Delcroix C, Salama AD, Fakhouri F. Heparin use during dialysis sessions induces an increase in the antiangiogenic factor soluble Flt1. Nephrol Dial Transplant. 2014 Jun;29(6):1225-31
Condon MB, Ashby D, Pepper RJ, Cook HT, Levy JB, Griffith M, Cairns TD, Lightstone L.Prospective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids. Ann Rheum Dis. 2013;72(8):1280-6.
Pepper RJ, Hamour S, Chavele KM, Todd SK, Rasmussen N, Flint S, Lyons PA, Smith KG, Pusey CD, Cook HT, Salama AD. Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis. KI 2013 Jun;83(6):1150-8.
Pepper RJ, Chanouzas D, Tarzi R, Little MA, Casian A, Walsh M, Pusey CD, Harper L, Salama AD; European Vasculitis Study (EUVAS) investigators. Intravenous cyclophosphamide and plasmapheresis in dialysis-dependent ANCA-associated vasculitis. CJASN 2013 Feb;8(2):219-24.
Pepper RJ, Salama AD. Classifying and predicting outcomes in ANCA-associated glomerulonephritis. NDT 2012 Jun;27(6):2135-7
Le Roux S, Pepper RJ (joint 1^st), Dufay A, Néel M, Meffray E, Lamandé N, Rimbert M, Josien R, Hamidou M, Hourmant M, Cook HT, Charreau B, Larger E, Salama AD, Fakhouri F. Elevated soluble Flt1 inhibits endothelial repair in PR3-ANCA-associated vasculitis. 2012 Jan;23(1):155-64 JASN
Holden NJ, Williams JM, Morgan MD, Challa A, Gordon J, Pepper RJ, Salama AD,Harper L, Savage CO. ANCA-stimulated neutrophils release BLyS and promote B cell survival: a clinically relevant cellular process. Ann Rheum Dis 2011 Dec;70(12):2229-33
Pepper R, Campbell N, Yaqoob MM, Roberts NB, Fan SL. Do oral aluminium phosphate binders cause accumulation of aluminium to toxic levels? BMC Nephrol. 2011 Oct 12;12:55
Pepper R, Griffith M, Kirwan C, Levy J, Taube D, Pusey C, Lightstone L, Cairns T. Rituximab is an effective treatment for lupus nephritis and allows a reduction in maintenance steroids. Nephrol Dial Trans. 2009 Dec;24(12):3717-23.
RJ Pepper, MA. Fabre, C Pavesio, G Gaskin, RB. Jones, D Jayne, CD. Pusey, AD. Salama. Rituximab is effective in the treatment of refractory Churg-Strauss syndrome and is associated with diminished T-cell interleukin-5 production.
Rheumatology (Oxford). 2008 Jul;47(7):1104-5.
AD Salama, HT Cook, CD Pusey, RJ Pepper. A Case of Treated ANCA-Associated Vasculitis with Recurrent Renal Failure. Clin J Am Soc Nephrol. 2008 Mar;3(2):637-45.
RJ Pepper, DP Gale, J Wajed, G Bommayya, D Ashby, A McLean, M Laffan, PH Maxwell. Inadvertent postdialysis anticoagulation due to heparin line locks. Hemodialysis International. 2007 Oct;11(4):430-4.
RJ Pepper, J Pati, AV Kaisary. The incidence and treatment of lymphoceles following radical retropubic prostatectomy. British Journal of Urology International. 2005 Apr;95(6) 772-775.
BOOK CHAPTERS
Lupus Nephritis: RJ Pepper and L Lightstone
Encyclopaedia of Medical Immunology; Springer
Immunosupression and rapidly progressive glomerulonephritis: RJ Pepper, AD Salama. Practical Nephrology (Springer)
Renal Emergencies (Chapter Editor)- Oxford Handbook of Acute Medicine.